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International Epilepsy Congress 2015 Istanbul

31st International Epilepsy Congress
Istanbul – September 2015

Despite the irresistible temptations of the city of Istanbul, the presence of 2,591 delegates from 160 countries in the Lütfi Kırdar Convention Center attested to the terrific performance of all the speakers and moderators. From antiepileptic drug trials including cannabinoids to genetics and surgery, from status epilepticus and immune related epilepsies to human rights and social issues, a great variety of topics were comprehensively covered by the speakers while stimulating panel discussions followed all the presentations.

Four prizes were awarded by Epilepsia, Epileptic Disorders, the Michael prize, and the new Harinarayan Young Neuroscientist Award endowed by the neurobiology commission and sponsored by the Harinarayan family to encourage young researchers.

The presidential symposium on one of the hot topics of genetics involved not only the most recent findings but also a touching story of a patient who was diagnosed with a calcium channel mutation after several years of work by a geneticist who was also her mother. The video of this session is available viewing here.

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News from ILAE All news

New ILAE Classification of Status Epilepticus

The Task Force on Classification of Status Epilepticus has published its report on the definition and classification, changing the concept of status epilepticus from a single entity into the more important and realistic view that the condition is a complex combination of cause and consequence that may require a more tailored approach. As new studies on status epilepticus are developed this classification will become a means of stratifying outcome risk and lead to a more useful evaluation of treatments which ultimately should be aimed to improving outcomes. The classification is available online and open access.

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News Around the World All news

Yes I can!
New photo competition for International Epilepsy Day - 8 February 2016

Yes I Can photo competition information

Enter the new photo competition for International Epilepsy Day 2016. The theme is "Yes, I can," to demonstrate achievement in overcoming obstacles, or achievement despite obstacles. The best photographs will form the International Epilepsy Day exhibition, taking place in the European Parliament in Strasbourg from Monday 1st to Friday 5th February 2016. Winners will receive US $1,000, and will be awarded in two categories. All entries will also be placed in a gallery on the International Epilepsy Day website. Deadline for entries: 10 January 2016

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Clinical Research News All news

Ketogenic diet exhibits anti-inflammatory properties


Dietary therapies like the ketogenic diet have been shown to be beneficial in epilepsy. In a recent study, scientists hypothesized that efficacy of the ketogenic diet is due to a decrease in inflammation. After being administered a regular diet or the ketogenic diet, rats were injected lipopolysaccharide (LPS) and downstream reactions were measured. Rats on the normal diet showed an increase in body temperature, whereas those on the ketogenic diet did not. Rats on the ketogenic diet also showed a decrease in proinflammatory cytokines in the blood (e.g TNFα and IL-1β) and brain in response to LPS. (Epilepsia 2015 DOI: 10.1111/epi.13038)

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Antiepileptic drugs and intrauterine death: A prospective observational study from EURAP

The most important risk factors for intrauterine death in pregnancies of women with epilepsy include maternal exposure to AED polytherapy and the presence of MCMs in at least one of the parents. T Tomson et al. Commentary: N Jetté. (Neurology 2015 85:580-588)

Relation between stress-precipitated seizures and the stress response in childhood epilepsy

Patients with epilepsy often report that stress can trigger seizures, but many physicians interpret this as recall bias. Van Campen et al. show that stress-sensitivity of seizures, determined either retrospectively or prospectively, correlates with a blunted cortisol response. (Brain 2015 138: 2234-2248)

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Basic Science of Epilepsy News All news

Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model

NMDAR antibody encephalitis is characterized by psychiatric symptoms like psychosis, paranoia and violent behavior, and may be followed by seizures. This study was done to examine the epileptogenicity of NMDAR antibodies in C57BL/6 mice. Administration of the antibody (IgG) into the lateral ventricle by itself did not cause spontaneous seizures, but exacerbated susceptibility of acute seizures caused by PTZ. Immunohistochemistry to visualize bound IgG showed that levels of IgG bound to the left hippocampus were proportional to seizure severity. This suggests that the IgG binds to, and causes internalization of NMDARs in the hippocampus, possibly leading to enhanced acutes eizures in response to PTZ.

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Microglial ROS production in an electrical rat post-status epilepticus model of epileptogenesis

Microglia are thought to contribute to epilepsy because they change shape and release reactive oxygen species (ROS). Most studies looking at microglial ROS production in epilepsy have been done after administration of a chemoconvulsant like pilocarpine or kainic acid. In the current study, the authors studied microglial ROS in an electrical status epilepticus (SE) model in rats. Using immunophenotyping to first identify microglia, the authors found an increase in microglial ROS two days after SE but not during epileptogenesis or epilepsy. Hence, anti-inflammatory strategies for epilepsy might be beneficial if they target the initial phase.

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Epileptic Disorders

Editor's Choice:
When patients with epilepsy or “epilepsy” might need a pacemaker. Invited Editorial Comment by John B.P. Stephenson

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Chapter Spotlight:
American Epilepsy Society

American Epilepsy Society

The American Epilepsy Society (AES) is the largest chapter of ILAE with more than 3,900 members. For nearly 80 years, AES has provided a dynamic global forum where professionals can learn, share and grow.

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New ILAE Classification of Status Epilepticus changes the concept of status epilepticus from a single entity into the more important and realistic view that the condition is a complex combination of cause and consequence that may require a more tailored approach.

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VIREPA EEG Basic Course

Application for the January 2016 Basic EEG Course is open for a limited amount of time.

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Epilepsy & Sports

Diane Borg, Maltese Sportswoman
Bodysurf 2011 champion Catarina Sousa with Teresa Peres
Stand Up For Epilepsy® and for full participation in sports.

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Epilepsy & Sport Project


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