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Announcing the launch of Epilepsia Open — the new open access journal of the International League Against Epilepsy. It publishes continuously upon acceptance and covers clinical, basic and translational research that expands current knowledge.

Editors-In-Chief

Aristea Galanopolou
Aristea Galanopoulou

Gary Mathern
Gary Mathern

Dieter Schmidt
Dieter Schmidt

Xuefeng Wang
Xuefeng Wang

Mission: to make original research for all aspects of high-quality epilepsy research widely available through open access publication, including early, preliminary studies on epilepsy that may provide new directions for clinical and laboratory research including negative and confirmatory studies.

Caret image More about Epilepsia Open

News from ILAE All news

EpilepsyDiagnosis.org now includes structural etiologies of the epilepsies

The structural etiology section of the EpilepsyDiagnosis.org diagnostic manual has been expanded to include details of major structural brain abnormalities that cause epilepsy, including the clinical context in which they occur, seizure types seen, EEG features, imaging features, genetic contributions, and differential diagnosis.

NEW Epilepsy Classification Roadmap

ILAE logo

The Classification of the Epilepsies moves forward – a roadmap for the development of an updated Classification is featured in Epilepsia Open. We present a framework to approach classification of patients in the clinic together with new concepts and terminology. We invite your comments for further refinement and consideration as we develop a Classification that will serve in clinical practice for the foreseeable future.


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News Around the World All news

Swiss Epilepsy League supports innovative research project
Epilepsie-Liga unterstützt innovatives Forschungsprojekt

Jean-Marc Fritschy and Tilo Gschwind
Jean-Marc Fritschy (left) and Tilo Gschwind

The Swiss League Against Epilepsy announces Prof. Jean-Marc Fritschy and Tilo Gschwind of the University of Zurich have been awarded this year's Research Grant of CHF 25,000. With the help of innovative optogenetics, the researchers are investigating the development of epilepsy and paving the way for new treatment methods. Applications are now open for next year's grant for start-up funding for research projects for the advancement of experimental or clinical research in the field of epileptology.

Call for nominations for the 2017 Michael Prize

Michael Prize

The Michael Prize is one of the most highly regarded international awards for the best contribution to scientific and clinical research which promote further developments in epileptology. Awarded biennially, it is specially designed to attract scientists not older than 45 years of age. Submission deadline: 31 December, 2016.

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Clinical Research News All news

WONOEP appraisal: Molecular and cellular biomarkers for epilepsy

Epilepsia

Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy. To date, no single peripheral biomarker has demonstrated proven effectiveness, although multiple candidates are in development. In this review, we discuss the major areas of focus including inflammation, blood-brain barrier dysfunction, redox alterations, metabolism, hormones and growth factors. Epilepsia. 4 July 2016. DOI: 10.1111/epi.13460


Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex

How seizure activity influences HG is not well understood. In a recent study, the authors used tissue obtained from resection of people with intractable epilepsy, microelectrode recordings from in vivo seizures, and modeling to see if HG activity could be a (better) indicator of the seizure onset zone (SOZ). The authors found that HG activity on a network level was correlated with paroxysmal depolarizing shifts (PDSs) that are seen on a neuronal level. eNeuro. 2016 May 23;3(2). doi: 10.1523

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Basic Science of Epilepsy News All news

Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures

Atypical febrile seizures are considered a risk factor for epilepsy onset and cognitive impairments later in life. Patients with temporal lobe epilepsy and a history of atypical febrile seizures often carry a cortical malformation. This association has led to the hypothesis that the presence of a cortical dysplasia exacerbates febrile seizures in infancy, in turn increasing the risk for neurological sequelae. The authors' findings demonstrate that KCC2 overexpression in a compromised developing brain increases febrile seizure susceptibility and contribute to dendritic spine alterations. (Neurobiology of Disease doi:10.1016/j.nbd.2016.02.014)

Caret image Summary for non-specialists


Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus

GABAergic neurotransmission depends on KCC1 and NKCC2 Cl− co-transporters; a dysfunction in these co-transporters is seen in neonatal seizures. Bumetanide – a drug that blocks NKCC1 chloride cotransporters – has been shown to be beneficial in seizures in neonates. In the current study, the authors wanted to test whether bumetanide would be useful in status epilepticus (SE) by using brain slice electrophysiology and in vivo EEG experiments. Administration of bumetanide reduced seizure-like events induced by zero-Mg+², and in intact mice by administration of kainic acid. As seizures progressed, diazepam led to pharmacoresistance, which bumetanide was able to overcome. Hence, this study suggests that there might be a new indication of bumetanide in SE.

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Chapter Spotlight:
Iraqi League Against Epilepsy

Iraqi League Against Epilepsy

IqLAE was first founded in 1999 at Neurosurgical Hospital-Baghdad for those medical personnel who are involved in the diagnosis, treatment and research in the field of Epileptology. It was rebuilt in 2010 in Al-Kindi General Hospital with a new, active Executive Committee.

Caret imageIraqi League Against Epilepsy

 

VIREPA Applications Now Open

Application for the 2016-2017 academic year will be accepted until August 3.

Caret image See VIREPA courses

 

New Guidelines

New Seizure Type Classification Proposed: Your comments are invited on on a new clinically-focused seizure type classification. The goal is to establish a final seizure classification scheme accepted by ILAE and the broad epilepsy community. Read proposal and comment here.

Caret imageRead all guidelines

 

ILAE eNewsletter

To subscribe, please provide your email address:
 

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Epilepsy & Sports

Diane Borg, Maltese Sportswoman
Bodysurf 2011 champion Catarina Sousa with Teresa Peres
Stand Up For Epilepsy® and for full participation in sports.

Caret imageBook, photos, and information about the
Epilepsy & Sport Project

 

 

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