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Lay Summary of Epilepsia Special Issue: Harmonization in Preclinical Epilepsy Research

Harmonization in preclinical epilepsy research: a joint AES/ILAE translational initiative.
Aristea S. Galanopoulou; Jacqueline A. French; Terence O’Brien; Michele Simonato

The optimization and harmonization of research practices in preclinical epilepsy research has been considered as an important translational initiative as it would allow data comparisons across laboratories, encourage multicenter collaborations and systematic reviews of preclinical data, as well as allow cross-validation of findings before entering clinical testing. The AES/ILAE Translational Task Force, a joint task force formed of members elected from the American Epilepsy Society (AES) and the International League Against Epilepsy (ILAE) undertook several initiatives towards this goal. A large number of volunteer investigators were assigned into different topic-oriented working groups. This introduction to the special issue on the proceedings of this Task Force describes the first reports that were produced by some of these working groups towards the creation of improved standards for performing and interpreting rodent electroencephalography (EEG) and electrophysiological studies, systematic reviews of preclinical data, and preclinical common data elements.

ILAE Genetics Commission blog

Interested in some general reading about the genetics and molecular neurobiology of epilepsies? Try the ILAE Genetics Commission blog: http://channelopathist.net/)

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