Lay summary of Epilepsia Special Issue: Harmonization in Preclinical Epilepsy Research

Harmonization in Preclinical Epilepsy Research: Summaries and links to each of the following articles

Harmonization in preclinical epilepsy research: a joint AES/ILAE translational initiative.
Aristea S. Galanopoulou; Jacqueline A. French; Terence O’Brien; Michele Simonato

The optimization and harmonization of research practices in preclinical epilepsy research has been considered as an important translational initiative as it would allow data comparisons across laboratories, encourage multicenter collaborations and systematic reviews of preclinical data, as well as allow cross-validation of findings before entering clinical testing. The AES/ILAE Translational Task Force, a joint task force formed of members elected from the American Epilepsy Society (AES) and the International League Against Epilepsy (ILAE) undertook several initiatives towards this goal. A large number of volunteer investigators were assigned into different topic-oriented working groups. This introduction to the special issue on the proceedings of this Task Force describes the first reports that were produced by some of these working groups towards the creation of improved standards for performing and interpreting rodent electroencephalography (EEG) and electrophysiological studies, systematic reviews of preclinical data, and preclinical common data elements.

Methodological standards and interpretation of video-EEG in adult control rodents. A TASK1-WG1 report of the AES/ILAE Translational Task Force of the ILAE

Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE

Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE

Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE

Identification and characterization of outcome measures reported in animal models of epilepsy. Protocol for a systematic review of the literature. A TASK2 report of the AES/ILAE Translational Task Force of the ILAE

Common data elements for preclinical epilepsy research: standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE

 Read the entire special issue here: Epilepsia Special Issue: Harmonization in Preclinical Epilepsy Research