JAMA Neurology

Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus

30 April, 2018

Marina Gaínza-Lein, Iván Sánchez Fernández, , Michele Jackson, et al.

JAMA Neurology April 2018 2018;75(4):410-418. doi:10.1001/jamaneurol.2017.4382

Question: Several studies have shown an association of prompt treatment with status epilepticus duration, but what is the association with other outcome measures, such as death?

Findings: In this multicenter observational study of 218 children with refractory convulsive status epilepticus, a delay in first-line benzodiazepine treatment was associated with death, the need for continuous infusions, longer convulsive duration, and more frequent hypotension.

Meaning: These findings may change the perception of acute seizure and status epilepticus treatment, tentatively converting it into an extremely time-sensitive emergency that is similar to stroke or other cardiovascular events.