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International Epilepsy Day

International Epilepsy Day - February 9

International Epilepsy Day is a joint initiative created by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). It is a global event celebrated annually on the 2nd Monday of February to promote awareness of epilepsy around the world. With IBE and ILAE representation in more than 120 countries, this is a powerful opportunity to highlight the problems faced by people with epilepsy in every region of the world.

This is a day for everyone and every organization, no matter where you are, no matter how small your group or how wide your geographical spread, no matter whether your focus is on the medical or on the social aspects of the disease, to join together and speak with one global voice to raise awareness and strengthen the epilepsy movement.

News from ILAE                                                                  All news

New! ILAE Leadership Development Program Scholarship

The ILAE is offering a Leadership Development Award to support the preparation and advancement of young physician leaders selected from ILAE chapters around the world. It affords a unique and exclusive opportunity to receive leadership development training, one-on-one guidance from a carefully selected mentor, and the opportunity to network with other rising leaders from around the globe. In 2015, its inaugural year, 15 candidates will be selected to participate in the program. More …

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ILAE eNews

Email newsletters can be blocked or filtered into a bulk folder or spam, especially now that email filters are focusing more strongly on “grey mail” or commercial mail. Even if mails have been received in the past, your filter may change at any time. To ensure you continue to receive the ILAE monthly digest, please add our email sender address (ILAE_News@mail.vresp.com) to your contacts or add the domain. Instructions here or request subscription.

CAOA Newsletter

CAOA 2014 newsletter

The 2014 CAOA Newsletter is now available, containing the annual report as well as reports on the 10th AOEC, the Indian Epilepsy Society, Japan Epilepsy Society, ASEPA, Purple Day, and Taiwan Epilepsy Society.

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News Around the World                                                      All news

Epilepsy Foundation Announces Shark Tank Competition

Epilepsy Foundation

The Epilepsy Foundation is accepting entries in its 4th Annual Shark Tank competition, which seeks innovative ideas for epilepsy treatment and care. Finalists will present their ideas at the 2015 Antiepileptic Drug and Device Trials XIII, taking place May 13 to 15 in Aventura, Fla. The winner will receive up to $200,000 to advance his or her concept. Letters of intent for the contest must be received by Feb. 16.

WHO issues report: Global burden of epilepsy and the need for coordinated action at the country level to address its health, social and public knowledge implications

WHO Report on Epilepsy

Report addressing burden and impact; challenges and gaps in care; international context and the Secretariat's activities; and improving epilepsy care: what is needed.

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Clinical Research News                                                        All news

IQ at 6 years after in utero exposure to antiepileptic drugs: A controlled cohort study

Researchers recruited children born to women with epilepsy (n = 243) and women without epilepsy (n = 287) during pregnancy and followed them prospectively to delineate the risk to child IQ associated with frequently prescribed antiepileptic drugs. Also see related editorial, "Fine-tuning risk assessment with antiepileptic drug use in pregnancy."

No evidence for human papillomavirus infection in focal cortical dysplasia IIb

The aetiology of Focal Cortical Dysplasia Type IIb (FCDIIb) remains enigmatic in patients suffering from drug-resistant epilepsy, and an aberrant activation of the mammalian target of rapamycin complex 1 signalling pathway (mTORC1) was detectedin this developmental brain malformation. Recently, the human papillomavirus (HPV) oncoprotein E6 has been identified as a potent activator of mTORC1. In this study, the authors tried to confirm two previous reports of HPV16 E6 infection using an independent series of 14 surgical specimens with histopathologically confirmed FCDIIb. (Annals of Neurology DOI: 10.1002/ana.24328)

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Basic Science of Epilepsy News                                           All news

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

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The authors of a recent study examined whether eslicarbazepine acetate (ESL) could target refractoriness to AEDs in addition to halting epileptogenesis. Using tissue resected from individuals with refractory epilepsy and pilocarpine- treated rodents, they found that ESL conferred use-dependent blockade of Na+ channels, hence alluding to its potential role in decreasing refractoriness. ESL was also found to block CaV3.2 calcium channels, mossy fiber sprouting and decrease neurodegeneration, hence having a likely beneficial role in slowing epileptogenesis. (Brain (2015) 138 (2): 371-387)

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

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Anti-epileptic drugs (AEDs) work only via a few known targets; the authors of a recent study investigated whether astrocytes could prove to be a potential avenue for novel AED discovery. Adeno-associated viral (AAV) vector was used to overexpress glutamine synthetase (GS) and excitatory amino-acid transporter 2 (EAAT2) to increase synaptic glutamate clearance. Additionally, microRNA technique was used to decrease expression of the enzyme adenosine kinase (ADK), and increase synaptic levels of adenosine – a naturally occurring anticonvulsant … more (Gene Therapy doi:10.1038/gt.2014.82)

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Chapter Spotlight:

Georgian League Against Epilepsy

The T. Geladze Georgian League Against Epilepsy was established in 1996 in Tbilisi, under the leadership of Prof. Tina Geladze, and became a member of the ILAE in 1997.

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ILAE eNewsletter

Free monthly email newsletter with brief highights of the ILAE's activities.

To subscribe, please provide your email address:

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Baltic Sea Summer School

Baltic Sea Summer School Group Discussion

The 8th BSSSE in Trakai, Lithuania in August received unusually high marks from participants. They appreciated the case-oriented studies, the early morning seminars on EEG, semiology and pharmacotherapy, and the tutorials in interactive groups.

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Definition of Epilepsy 2014 - New definition and commentaries.

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