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Announcing the launch of Epilepsia Open — the new open access journal of the International League Against Epilepsy. It publishes continuously upon acceptance and covers clinical, basic and translational research that expands current knowledge.

Editors-In-Chief

Aristea Galanopolou
Aristea Galanopoulou

Gary Mathern
Gary Mathern

Dieter Schmidt
Dieter Schmidt

Xuefeng Wang
Xuefeng Wang

Mission: to make original research for all aspects of high-quality epilepsy research widely available through open access publication, including early, preliminary studies on epilepsy that may provide new directions for clinical and laboratory research including negative and confirmatory studies.

Caret image More about Epilepsia Open

News from ILAE All news

NEW Epilepsy Classification Roadmap

ILAE logo

The Classification of the Epilepsies moves forward – a roadmap for the development of an updated Classification is featured in Epilepsia Open. We present a framework to approach classification of patients in the clinic together with new concepts and terminology. We invite your comments for further refinement and consideration as we develop a Classification that will serve in clinical practice for the foreseeable future.


Samuel Wiebe Elected ILAE President, 2017-2021 term

Sam Wiebe
Samuel Wiebe

Sam Wiebe was elected with 68% of the eligible votes in the election by ILAE chapter members that concluded 2 May 2016.
Results details | Statement |  Curriculum vitae
Complete election process.

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John Pellock (1943-2016)

Jack Pellock

When Dr John (Jack) M Pellock recently died surrounded by family and close friends after a long battle with pancreatic cancer, we lost a colleague, mentor and friend whose contributions will long be remembered. Jack Pellock was a leading figure in pediatric epilepsy, a passionate advocate for children with epilepsy and a mentor and friend to several generations of child neurologists. He will be sorely missed but his memory and contributions will be with us for years to come.

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News Around the World All news

Call for nominations for the 2017 Michael Prize

Michael Prize

The Michael Prize is one of the most highly regarded international awards for the best contribution to scientific and clinical research which promote further developments in epileptology. Awarded biennially, it is specially designed to attract scientists not older than 45 years of age. Submission deadline: 31 December, 2016.

 


Elio Lugaresi (1926 – 2015)

Elio Lugaresi obituary

Prof. Elio Lugaresi passed away on December 22, 2015 in his 89th year. His passing leaves many in the neurologic community reflecting on his enormous legacy to the discipline.

Elio Lugaresi's career was devoted to the study of neurology, neurophysiology, epilepsy, and above all sleep in all its aspects, a passion he pursued well into retirement.

 

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Clinical Research News All news

Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex

How seizure activity influences HG is not well understood. In a recent study, the authors used tissue obtained from resection of people with intractable epilepsy, microelectrode recordings from in vivo seizures, and modeling to see if HG activity could be a (better) indicator of the seizure onset zone (SOZ). The authors found that HG activity on a network level was correlated with paroxysmal depolarizing shifts (PDSs) that are seen on a neuronal level. eNeuro. 2016 May 23;3(2). doi: 10.1523


A reappraisal of mortality after epilepsy surgery

Brain surgery is associated with a reduction in mortality rate in drug-resistant epilepsy, both when seizures are abolished and when it results in significant palliation of tonic-clonic seizure frequency. These observations provide further rationale for earlier consideration of epilepsy surgery. Neurology May 24, 2016 vol. 86 no. 21 1938-1944

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Basic Science of Epilepsy News All news

Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures

Atypical febrile seizures are considered a risk factor for epilepsy onset and cognitive impairments later in life. Patients with temporal lobe epilepsy and a history of atypical febrile seizures often carry a cortical malformation. This association has led to the hypothesis that the presence of a cortical dysplasia exacerbates febrile seizures in infancy, in turn increasing the risk for neurological sequelae. The authors' findings demonstrate that KCC2 overexpression in a compromised developing brain increases febrile seizure susceptibility and contribute to dendritic spine alterations. (Neurobiology of Disease doi:10.1016/j.nbd.2016.02.014)

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Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus

GABAergic neurotransmission depends on KCC1 and NKCC2 Cl− co-transporters; a dysfunction in these co-transporters is seen in neonatal seizures. Bumetanide – a drug that blocks NKCC1 chloride cotransporters – has been shown to be beneficial in seizures in neonates. In the current study, the authors wanted to test whether bumetanide would be useful in status epilepticus (SE) by using brain slice electrophysiology and in vivo EEG experiments. Administration of bumetanide reduced seizure-like events induced by zero-Mg+², and in intact mice by administration of kainic acid. As seizures progressed, diazepam led to pharmacoresistance, which bumetanide was able to overcome. Hence, this study suggests that there might be a new indication of bumetanide in SE.

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Chapter Spotlight:
Iraqi League Against Epilepsy

Iraqi League Against Epilepsy

IqLAE was first founded in 1999 at Neurosurgical Hospital-Baghdad for those medical personnel who are involved in the diagnosis, treatment and research in the field of Epileptology. It was rebuilt in 2010 in Al-Kindi General Hospital with a new, active Executive Committee.

Caret imageIraqi League Against Epilepsy

 

VIREPA Applications Now Open

Application for the 2016-2017 academic year will be accepted until August 3.

Caret image See VIREPA courses

 

New Guidelines

New Seizure Type Classification Proposed: Your comments are invited on on a new clinically-focused seizure type classification. The goal is to establish a final seizure classification scheme accepted by ILAE and the broad epilepsy community. Read proposal and comment here.

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ILAE eNewsletter

To subscribe, please provide your email address:
 

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Epilepsy & Sports

Diane Borg, Maltese Sportswoman
Bodysurf 2011 champion Catarina Sousa with Teresa Peres
Stand Up For Epilepsy® and for full participation in sports.

Caret imageBook, photos, and information about the
Epilepsy & Sport Project

 

 

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