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New at Epileptic Disorders

The official educational journal of the ILAE has launched a number of new initiatives, including:

www.epilepticdisorders.com now has multimedia teaching material:

  • a comprehensive video library of short educational videos on specific aspects of seizure semiology and electroclinical features of epilepsy syndromes;
  • structural and/or functional neuroimaging and neuropathology images;
  • EEG and MEG figures; and videos or images of neurosurgical techniques.

Submission of material for this section is welcomed (see website for details).

  • Seminars in Epileptology and Learning from History
    Review-style articles of high didactic value relevant to general neurologists and child neurologists, which focus on general knowledge or everyday clinical practice and care in the field of epilepsy.
  • Electroclinical Reasoning Reports
    Providing a comprehensive approach for diagnostic or presurgical evaluation of complex epilepsy patients and epilepsy surgery strategies. Manuscripts include an introduction and hypotheses regarding an epilepsy syndrome or epileptogenic zone(s), justification of the investigations chosen to support the hypotheses, and conclusions based on the investigations. Importantly, as a challenge to the reader, the final diagnosis or therapeutic strategy only appears at the end of the report.

Several questions appear at the end of each article, with answers accessed on the website.

News from ILAE All news

Epilepsy Awareness Day November 4-5, 2015

Epilepsy Awareness Day 2015 Disneyland

Honoring the ILAE and the IBE for their efforts in uniting the world's epilepsy communities and the launch of International Epilepsy Day!

Epilepsy Awareness and Education Expo, November 4: Bringin patients and families together with Epilepsy professionals, in order to get everyone as much support as possible.

Epilepsy Awareness Day, November 5: Founded to unite the epilepsy community, to bring epilepsy out of the shadows, and to stomp out epilepsy stigma. More …

Jean Aicardi, 1926 – 2015

Jean Aicardi

It is with a great sense of sadness and loss that we learned of the passing of Jean Aicardi, who died the morning of August 3, 2015. Jean was born in 1926 in Rambouillet, France. He earned his MD from the Faculté de Médecine in Paris in 1955 and had his early professional training at the Hôpital des Enfants Malades, also in Paris. It is how he lived those many years that made him an extraordinary figure in epilepsy and child neurology. His entry into this field was not planned, rather it came about through almost chance encounters in his early training in Paris with mentors and colleagues who were interested in neurology and children. As with many highly successful people, he found a path forward through many obstacles, including the lack of formal support for physicians who wished to enter the field of child neurology. More …

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News Around the World All news

SUDEP Awareness Day 23 October 2015: Are you SUDEP savvy?

SUDEP Awareness Day 2015

SUDEP Awareness Day was created by UK charity SUDEP Action and is dedicated to raising awareness of SUDEP all around the world. It was launched last year and was supported by 45 epilepsy organisations from around the world. SUDEP Awareness Day is celebrated annually on 23 October.

World Stroke Day 2015: Stroke affects women, stroke affects everyone.

World Stroke Day

World Stroke Day is on Thursday the 29th October 2015. The World Stroke Organization's theme for World Stroke Day 2015 is "I am Woman." The World Stroke Organization is calling on communities and individuals to use World Stroke Day to show they care. Share information about stroke prevention and ask the women in your community and your life to have a health check to avoid preventable stroke and cardiovascular disease.

World Stroke Day Proclamation | World Stroke Campaign

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Clinical Research News
All news

Ketogenic diet exhibits anti-inflammatory properties


Dietary therapies like the ketogenic diet have been shown to be beneficial in epilepsy. In a recent study, scientists hypothesized that efficacy of the ketogenic diet is due to a decrease in inflammation. After being administered a regular diet or the ketogenic diet, rats were injected lipopolysaccharide (LPS) and downstream reactions were measured. Rats on the normal diet showed an increase in body temperature, whereas those on the ketogenic diet did not. Rats on the ketogenic diet also showed a decrease in proinflammatory cytokines in the blood (e.g TNFα and IL-1β) and brain in response to LPS. (Epilepsia 2015 DOI: 10.1111/epi.13038)

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Antiepileptic drugs and intrauterine death: A prospective observational study from EURAP

The most important risk factors for intrauterine death in pregnancies of women with epilepsy include maternal exposure to AED polytherapy and the presence of MCMs in at least one of the parents. T Tomson et al. Commentary: N Jetté. (Neurology 2015 85:580-588)

Relation between stress-precipitated seizures and the stress response in childhood epilepsy

Patients with epilepsy often report that stress can trigger seizures, but many physicians interpret this as recall bias. Van Campen et al. show that stress-sensitivity of seizures, determined either retrospectively or prospectively, correlates with a blunted cortisol response. (Brain 2015 138: 2234-2248)

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Basic Science of Epilepsy News All news

Glycine transporter 1 is a target for the treatment of epilepsy

Glycine is an important modulator of synaptic plasticity in the hippocampus, but its role in epilepsy is not very well understood. In a recent study, the authors used two models of TLE – the intrahippocampal kainic acid model in mice and tetanic stimulation in rats, and observed effects on the glycine transporter 1 (GlyT1). In both rats and mice, the authors found an increase in protein levels of GlyT1. An increase in mRNA for GlyT1 was found in tissue resected from subjects with TLE. In a third experiment, mice with genetic deletion of GlyT1 in hippocampus and those administered the GlyT1 inhibitor LY showed an increased seizure threshold suggestive of a protective effect of decreasing glycine activity. Hence, the GlyT1 could be a potential novel target for development of new AEDs.

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Astrocyte uncoupling as a cause of human temporal lobe epilepsy

Astrogliosis (marked by hypertrophy of astrocytes and upregulation of astrocyte-specific markers) has been suggested to be proconvulsive in temporal lobe epilepsy. In this study, the authors show that there is loss of gap junction coupling between astrocytes in tissue resected from people with epilepsy with hippocampal sclerosis; this could underlie improper buffering of K+ ions. … Using an animal model of epilepsy, the authors also show that astrocytic uncoupling is a fairly early process in epileptogenesis. Hence, one can hypothesize that halting astrocytic uncoupling after an initiating event could stop epileptogenesis.

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Epileptic Disorders

Editor's Choice:
When patients with epilepsy or “epilepsy” might need a pacemaker. Invited Editorial Comment by John B.P. Stephenson

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Chapter Spotlight:

Swedish Epilepsy Society

The Swedish Epilepsy Society, founded in 1986, has about 400 members. They offer an annual scientific meeting and frequent workshops and seminars. Read more about their activities and focus and view their video.

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VIREPA Application Deadline Extended!

Please see VIREPA course details for information and deadlines for 2015-2016 Academic Year courses.

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Epilepsy & Sports

Diane Borg, Maltese Sportswoman
Maltese Sportswoman of the Year
Diane Borg and friend
Stand Up For Epilepsy® and for full participation in sports.

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Definition of Epilepsy 2014 - New definition and commentaries.

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ILAE eNewsletter

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