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Report from the 8th Latin American Congress on Epilepsy (LACE)


The 8th Latin-American Congress was held in Buenos Aires, September 17 - 20, 2014. The Congress was attended by more than 750 delegates from 40 countries. The program covered a broad range of topics and featured eminent speakers from the region and around the world. A total of 182 abstracts were submitted from centers across America on subjects ranging from cutting-edge basic science to critical community and epidemiological work.

Main sessions included epilepsy in children, epileptic encephalopathy, non-convulsive status epilepticus, and genetics, as well as epidemiological, psychiatric, and neuropsychological aspects and epilepsy translational research. The parallel sessions covered anticonvulsant cost, side effects, and generics, epilepsy surgery in children and adults in America, the ketogenic diet, and epilepsy in the tropics.

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News from ILAE                                                                  All news

CAOA Newsletter

CAOA 2014 newsletter

The 2014 CAOA Newsletter is now available, containing the annual report as well as reports on the 10th AOEC, the Indian Epilepsy Society, Japan Epilepsy Society, ASEPA, Purple Day, and Taiwan Epilepsy Society.

Use of valproate in women and girls

Letter to the EMA (European Medicines Agency) from the ILAE Commission on European Affairs (CEA), ILAE Commission on Medical Therapies, and ILAE Task Force on AED Trials and Regulatory Affairs regarding PRAC recommendations to strengthen the restrictions on the use of valproate in women and girls.
ILAE Letter | EMA PRAC Recommendation

International Epilepsy Day

Epilepsy Day

An important way to "bring epilepsy out of the shadows" and educate the public about modern concepts that epilepsy is a disease like any other is through awareness. The International Epilepsy Day is the focus of a series of letters and commentaries collected by Epilepsia. The Executive Committees of ILAE and IBE have voted in favor of holding International Epilepsy Day on the second Monday of February. Commentaries and letters compiled by Epilepsia.

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News Around the World                                                      All news
New book: MRI-Negative Epilepsy

Elson So and Philippe Ryvlin have announced the publication of their new book, MRI-Negative Epilepsy, and are graciously donating the editors' royalties to the ILAE. Each chapter critically appraises the role and value of specific diagnostic and treatment techniques to address the challenges of MRI-negative epilepsy surgery.

Yukio Fukuyama

Farewell: Yukio Fukuyama

It is with great sadness that we announce the death of Professor Yukio Fukuyama, a true pioneer in the field of pediatric neurology who chaired the Department of Pediatrics at Tokyo Women’s Medical University, for a quarter of a century, teaching and mentoring young doctors and leading us into the 21st century.

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Clinical Research News                                                        All news

No evidence for human papillomavirus infection in focal cortical dysplasia IIb

The aetiology of Focal Cortical Dysplasia Type IIb (FCDIIb) remains enigmatic in patients suffering from drug-resistant epilepsy, and an aberrant activation of the mammalian target of rapamycin complex 1 signalling pathway (mTORC1) was detectedin this developmental brain malformation. Recently, the human papillomavirus (HPV) oncoprotein E6 has been identified as a potent activator of mTORC1. In this study, the authors tried to confirm two previous reports of HPV16 E6 infection using an independent series of 14 surgical specimens with histopathologically confirmed FCDIIb. (Annals of Neurology DOI: 10.1002/ana.24328)

Complete remission of childhood-onset epilepsy: stability and prediction over two decades

Berg et al. report that complete remission of paediatric epilepsy occurs in about 60% of patients over the course of 20 years. This outcome can be predicted with fair accuracy based on initial clinical factors, and good accuracy based on early seizure outcomes over the first 2-5 years. (Brain 2014 137: 3213-3222)

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Basic Science of Epilepsy News                                           All news

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

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Anti-epileptic drugs (AEDs) work only via a few known targets; the authors of a recent study investigated whether astrocytes could prove to be a potential avenue for novel AED discovery. Adeno-associated viral (AAV) vector was used to overexpress glutamine synthetase (GS) and excitatory amino-acid transporter 2 (EAAT2) to increase synaptic glutamate clearance. Additionally, microRNA technique was used to decrease expression of the enzyme adenosine kinase (ADK), and increase synaptic levels of adenosine – a naturally occurring anticonvulsant … more (Gene Therapy doi:10.1038/gt.2014.82)

Tau reduction prevents disease in a mouse model of Dravet syndrome

Tau ablation prevented the high mortality of Dravet mice and reduced the frequency of spontaneous and febrile seizures. It reduced interictal epileptic spikes in vivo and drug-induced epileptic activity in brain slices ex vivo. Tau ablation also prevented biochemical changes in the hippocampus indicative of epileptic activity and ameliorated abnormalities in learning and memory, nest building, and open field behaviors in Dravet mice. Deletion of only 1 Tau allele was sufficient to suppress epileptic activity and improve survival and nesting performance.

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Chapter Spotlight:
United Arab Emirates

Fundamentals of Epilepsy faculty, 2013
Faculty for Fundamentals of Epilepsy for Non-Neurologists, 2013

The Emirati League is a newer chapter of the ILAE, formed in 2005. Since 2011, they have had remarkable achievements in helping people who have epilepsy, and in generating resources to further the mission through organized activities and volunteering.

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Baltic Sea Summer School

Baltic Sea Summer School Group Discussion

The 8th BSSSE in Trakai, Lithuania in August received unusually high marks from participants. They appreciated the case-oriented studies, the early morning seminars on EEG, semiology and pharmacotherapy, and the tutorials in interactive groups.

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Newly added VIREPA EEG Course

Newly Added EEG Basic course now available

Dates: January 17 – June 29, 2015. Space is very limited.

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Definition of Epilepsy 2014 - New definition and commentaries.

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ILAE eNewsletter

Free monthly email newsletter with brief highights of the ILAE's activities.

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