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Report from the 8th Latin American Congress on Epilepsy (LACE)


The 8th Latin-American Congress was held in Buenos Aires, September 17 - 20, 2014. The Congress was attended by more than 750 delegates from 40 countries. The program covered a broad range of topics and featured eminent speakers from the region and around the world. A total of 182 abstracts were submitted from centers across America on subjects ranging from cutting-edge basic science to critical community and epidemiological work.

Main sessions included epilepsy in children, epileptic encephalopathy, non-convulsive status epilepticus, and genetics, as well as epidemiological, psychiatric, and neuropsychological aspects and epilepsy translational research. The parallel sessions covered anticonvulsant cost, side effects, and generics, epilepsy surgery in children and adults in America, the ketogenic diet, and epilepsy in the tropics.

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News from ILAE                                                                  All news

Use of valproate in women and girls

Letter to the EMA (European Medicines Agency) from the ILAE Commission on European Affairs (CEA), ILAE Commission on Medical Therapies, and ILAE Task Force on AED Trials and Regulatory Affairs regarding PRAC recommendations to strengthen the restrictions on the use of valproate in women and girls.
ILAE Letter | EMA PRAC Recommendation

International Epilepsy Day

Epilepsy Day

An important way to "bring epilepsy out of the shadows" and educate the public about modern concepts that epilepsy is a disease like any other is through awareness. The International Epilepsy Day is the focus of a series of letters and commentaries collected by Epilepsia. The Executive Committees of ILAE and IBE have voted in favor of holding International Epilepsy Day on the second Monday of February. Commentaries and letters compiled by Epilepsia.

Temporary changes at Epilepsia

Gary Mathern

Owing to an unexpected illness Gary Mathern will need to step back from Epilepsia for a while. To ensure continued smooth handling of all Epilepsia matters the Executive Committee has given unanimous support to the appointment of Mike Sperling as an interim Co-Editor in Chief. Mike will be working in close partnership with Epilepsia’s other Co-editor-in-Chief, Astrid Nehlig.

We are grateful to Mike for taking the helm at such short notice, and wish Gary a full recovery, expecting to see him back at the helm in due course. A word from Gary Mathern

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News Around the World                                                      All news
New book: MRI-Negative Epilepsy

Elson So and Philippe Ryvlin have announced the publication of their new book, MRI-Negative Epilepsy, and are graciously donating the editors' royalties to the ILAE. Each chapter critically appraises the role and value of specific diagnostic and treatment techniques to address the challenges of MRI-negative epilepsy surgery.

Yukio Fukuyama

Farewell: Yukio Fukuyama

It is with great sadness that we announce the death of Professor Yukio Fukuyama, a true pioneer in the field of pediatric neurology who chaired the Department of Pediatrics at Tokyo Women’s Medical University, for a quarter of a century, teaching and mentoring young doctors and leading us into the 21st century.

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Clinical Research News                                                        All news
Epilepsy: Pregnancy in women with epilepsy – risks and management

The risks of seizures and antiepileptic drug (AED) teratogenicity must be balanced when treating pregnant women with epilepsy. Two recent articles address these risks for newer AEDs. Lamotrigine and levetiracetam carried low risks of malformations, and topiramate exhibited a dose-dependent risk. Levetiracetam controlled seizures more effectively than lamotrigine and topiramate. (doi:10.1038/nrneurol.2014.179)

Prolonged Epileptic Seizures: Identification and Rescue Treatment Strategies

Epileptic Disorders Supplement 2014

Understanding of the mechanisms underlying the predisposition for prolonged seizures may lead to improved management pathways. The contributions published in this supplement of Epileptic Disorders are the final product of constructive debates held during an international experts workshop devoted to the topic of prolonged seizures, particularly in children.

Epileptic Disorders, Vol. 16, Supplement 1, October 2014

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Basic Science of Epilepsy News                                           All news

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

Anti-epileptic drugs (AEDs) work only via a few known targets; the authors of a recent study investigated whether astrocytes could prove to be a potential avenue for novel AED discovery. Adeno-associated viral (AAV) vector was used to overexpress glutamine synthetase (GS) and excitatory amino-acid transporter 2 (EAAT2) to increase synaptic glutamate clearance. Additionally, microRNA technique was used to decrease expression of the enzyme adenosine kinase (ADK), and increase synaptic levels of adenosine – a naturally occurring anticonvulsant … more (Gene Therapy doi:10.1038/gt.2014.82) Short summary for non-specialists

Tau reduction prevents disease in a mouse model of Dravet syndrome

Tau ablation prevented the high mortality of Dravet mice and reduced the frequency of spontaneous and febrile seizures. It reduced interictal epileptic spikes in vivo and drug-induced epileptic activity in brain slices ex vivo. Tau ablation also prevented biochemical changes in the hippocampus indicative of epileptic activity and ameliorated abnormalities in learning and memory, nest building, and open field behaviors in Dravet mice. Deletion of only 1 Tau allele was sufficient to suppress epileptic activity and improve survival and nesting performance.

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From the Editors:
A White Paper on the medical and social needs of people with epilepsy and intellectual disability: The Task Force on Intellectual Disabilities and Epilepsy of the International League Against Epilepsy. Kerr et al.

New Articles (22 November, 2014)
November Table of Contents

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Chapter Spotlight:

YoungStar Training Program
President Günter Krämer presenting the Tissot Medal to Giuseppe Scollo-Lavizzari

The Swiss League Against Epilepsy was founded in 1931 and has been a Chapter of the ILAE since 1964. Their goal is to enhance research in epileptology and inform the public on epilepsy issues to improve the medical and psychosocial situation for people with epilepsy.

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Baltic Sea Summer School

Baltic Sea Summer School Group Discussion

The 8th BSSSE in Trakai, Lithuania in August received unusually high marks from participants. They appreciated the case-oriented studies, the early morning seminars on EEG, semiology and pharmacotherapy, and the tutorials in interactive groups.

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Newly added VIREPA EEG Course

Newly Added EEG Basic course now available

Dates: January 17 – June 29, 2015. Space is very limited.

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Definition of Epilepsy 2014 - New definition and commentaries.

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ILAE eNewsletter

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