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A Population Based Strategy for Comprehensive Epilepsy Care in Ontario, Canada


O. Carter Snead III, M.D.

Ontario has 95,000 people with epilepsy, 15,000 of whom are children. As is true everywhere else in the world, about one-third of these people have medically refractory epilepsy, and prior to 2013 the care that Ontarians with epilepsy received was uneven and their access to surgical evaluation varied from capricious to non-existent, even in the face of a very good single-payer health care system.

Carter Snead, Co-Chair, Ontario Epilepsy Implementation Task Force, details how his task force helped develop an integrated system for epilepsy care and education in Ontario.

Caret image Full article and Ontario Guidelines

News from ILAE All news

Call for Wikipedia Epilepsy Editor

The International League Against Epilepsy (ILAE) invites applicants and nominations for the position of Editor-in-Chief of its new Wikipedia Epilepsy initiative. This presents the ILAE with a unique opportunity to convey through Wikipedia the most authoritative and up-to-date information on epilepsy … Qualifications, responsibilities and application process.


Award nominations now open

Frederick Andermann
Frederick Andermann
2015 Lifetime Achievement Award

Nominations are now open for three prestigious awards to be presented by the ILAE and IBE at the 32nd International Epilepsy Congress in Barcelona in 2017: Ambassador for Epilepsy Awards, Social Accomplishment in Epilepsy Award, and the Lifetime Achievement Award. The closing date for receipt of nominations for all three awards is December 31, 2016. Read nomination instructions


New Epileptologist Competencies Survey

The ILAE is developing an educational curriculum for Epileptologists.We need you to help us identify the competencies that are important for training Epileptologists and that should be included in an educational curriculum. This is an anonymous survey. Complete survey here: www.surveymonkey.com/r/epileptologistcompetencies


ILAE Epigraph Newsletter

ILAE logo

From the Information Officer| From the President | Brain Recovery Project | Epilepsy Care in Canada | Epilepsy Education in Latin America | EpilepsyDiagnosis.org | Epilepsy Awareness Day | 20th Anniversary of Thai Epilepsy Society | ILAE Journals | Upcoming Congresses | Download complete issue as PDF | Read Epigraph online

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News Around the World All news

Epilepsy Alliance Europe announces website

Epilepsy Alliance Europe, a not-for-profit organization established under the auspices of the ILAE and the IBE, has launched a new website, EpilepsyAllianceEurope.org. Read more about the organization and the website in the October 2016 newsletter


Opportunity to Comment on H2020 - Deadline 15 January 2017

The European Commission has just launched a public stakeholder consultation which will feed into the interim evaluation of Horizon 2020. This is an opportunity for members of our community to express their view on how the H2020 framework program has contributed to epilepsy research. More …


Putting Epilepsy in the Picture

International Epilepsy Day

Art Competition to celebrate International Epilepsy Day 2017
Entry deadline: 31 December 2016

More about the contest

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Clinical Research News All news

Malformations of cortical development

Malformations of cortical development (MCDs) compose a diverse range of disorders that are common causes of neurodevelopmental delay and epilepsy. This review discusses genetic and molecular alterations that disrupt normal cortical development, with emphasis on recent discoveries, and provide detailed radiological features of the most common and important MCDs. (Ann Neurol 2016) More …


Diagnostic accuracy of the Salzburg EEG criteria for non-convulsive status epilepticus: a retrospective study

Several EEG criteria have been proposed for diagnosis of non-convulsive status epilepticus (NCSE), but none have been clinically validated. We aimed to assess the diagnostic accuracy of the EEG criteria proposed by a panel of experts at the fourth London-Innsbruck Colloquium on Status Epilepticus in Salzburg, 2013 (Lancet). More …


Comorbidity and Childhood Epilepsy: A Nationwide Registry Study

The overall frequency of comorbid disease is high in children with epilepsy, including children with presumably uncomplicated epilepsies. (Pediatrics September 2016, volume 138 /issue 3.) More …

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Basic Science of Epilepsy News All news

Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors

Dynamic changes in intracellular ion concentrations are central to the initiation and progression of epileptic seizures. However, it is not known how changes in intracellular H+ concentration (ie, pH) differ between different cell types during seizures. Using recently developed pH-sensitive proteins, we demonstrate that astrocytes undergo rapid alkalinization during periods of seizure-like activity, which is in stark contrast to the acidification that occurs in neighboring neurons. (doi: 10.1523/JNEUROSCI.0664-16.2016)

Caret image Summary for non-specialists


Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures

Atypical febrile seizures are considered a risk factor for epilepsy onset and cognitive impairments later in life. Patients with temporal lobe epilepsy and a history of atypical febrile seizures often carry a cortical malformation. This association has led to the hypothesis that the presence of a cortical dysplasia exacerbates febrile seizures in infancy, in turn increasing the risk for neurological sequelae. The authors' findings demonstrate that KCC2 overexpression in a compromised developing brain increases febrile seizure susceptibility and contribute to dendritic spine alterations. (Neurobiology of Disease doi:10.1016/j.nbd.2016.02.014)

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