Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks

Features

• Presents the work of many experts in the field of epilepsy and sudden death
• Establishes risk factors for and mechanisms of sudden death in persons with epilepsy (SUDEP)
• Includes clinical case studies, patient investigation and management, mechanistic proposals, predictive models, and potential therapies
• Discusses how neurologists, emergency room physicians, and attending physicians can identify individuals at risk for SUDEP and possibly lessen the chance of occurrence
• Provides a database of over 100 cases showing clusters of risk factors

Summary

Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classification System and Risk Factor Cluster ID method will help to address gaps in our knowledge about the causes and possible prevention of this tragic complication.

Exploring the interactions among the central and peripheral autonomic nervous systems and the cardiopulmonary systems, the book includes case studies of SUDEP, definite or probable, as well as near miss cases. It discusses how neurologists, emergency room physicians, and attending physicians can identify individuals at possible risk for SUDEP and lessen the chance of occurrence. Top medical professionals in the field detail the development of an international database of human cases and animal models of SUDEP and suggest how medical examiner and coroner offices can strengthen the database by providing information about incidences of SUDEP. In addition, the book describes related clinical and animal studies needed to classify risk factors for SUDEP victims.

Understanding the risk factors and mechanisms underlying SUDEP will facilitate collaborative research in the laboratory, hospital, and clinic and lead to improved effectiveness of SUDEP prevention strategies.