Drug-Resistant Epilepsy
Despite medications, one-third of people with epilepsy continue to have seizures. In some patients with drug-resistant epilepsy, surgical or stimulation-based treatments can be considered. Refer to Epilepsy Surgery.
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Definition of drug resistant epilepsy: Consensus proposal by the ad hoc task force of the ILAE Commission on Therapeutic Strategies (2009)
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The chances of seizure freedom after two anti-seizure medications fail (Epigraph, 2020)
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New Anti-Epileptic Drugs have not improved overall outcomes (Epigraph, 2018)
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American Academy of Neurology guideline for the treatment of neurocysticercosis. Baird et al., Evidence-based guideline: Treatment of parenchymal neurocysticercosis: Report of the Guideline Development Subcommittee of the American Academy of Neurology. 2013 Apr 9;80(15):1424-9.(2013)
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What are the minimum requirements for ketogenic diet services in resource-limited regions? Recommendations from the ILAE Task Force for Dietary Therapy. Kossoff et al. What are the minimum requirements for ketogenic diet services in resource‐limited regions? Recommendations from the International League Against Epilepsy Task Force for Dietary Therapy. Epilepsia. Sep;56(9):1337-42 (2015)
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Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Kanner et al. Neurology. 2018 Jul 10;91(2):82-90.
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Psychological treatments for adults and children with epilepsy:Evidence-based recommendations by the International League Against Epilepsy Psychology Task Force.
Michaelis R, Tang V, Goldstein LH, et al. Epilepsia 2018 59:1282-1302. -
Refractory Epilepsy (Difficult to Treat Seizures): Epilepsy Foundation (2014)
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Georgian Protocol: Diagnosis and management of pharmacoresistant epilepsy (ეპილეფსიის ფარმაკორეზისტენტული ფორმების დიაგნოსტიკა და მართვა)
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