Proposed classification: Syndromes in Neonates and Infants

Members of the Nosology and Definitions Task Force of the ILAE have developed four position papers on syndrome definitions at various ages. The ILAE guideline process requires obtaining feedback and comments from its members on the proposed paper. These comments from our international community will be reviewed by the working group before finalizing the paper.

Please see the Draft: ILAE Classification & Definition of Epilepsy Syndromes in the Neonate and Infant

The manuscript will be open for comments until 15 June 2021. Please use this survey to enter your comments and they will be published below.

Thank you for your help in this important effort of the ILAE.

See all four Proposed papers for Nosology and Definitions

Comments

10 May 2021

In the article, in the part of "Self-Limited (Familial) Infantile Epilepsy" it is so written "The interictal EEG is typically normal, but a variant with midline spikes during slow sleep has been described". Capovilla et al first published this variant, describing both the EEG marker and the ictal clinical semeiology, proposing it as a new epileptic syndrome in 2000 (Brain & Development 22 (2000) 93-98) and updated it in 2006 in another article (Brain & Development 28 (2006) 85–91). None of these articles are cited among the references. The authors should revise the text and correctly describe how this variant has been proposed to the scientific community.

Giuseppe Capovilla


8 May 2021

For the developmental and epileptic encephalopathy patients, we should [include] a guidance on how to classify them into:

  1. Othahara
  2. EME
  3. MeUNCLAtabolic
  4. Migrating partial epilepsy
  5. West Syndrome 
  6. LGS 6) Dravet
  7. Electrical status in sleep/LKS
  8. Unclassified

This should also help research as also to identify genes responsible for various sub types of DEE.

Vivek Jain