Guidelines & Reports

The current state of epilepsy guidelines (December 2015)

Management

• Premature mortality of epilepsy in low- and middle-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy (2016)
• The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy (2016)
• Treatment of Convulsive Status Epilepticus (American Epilepsy Society 2016)
• NICE Guidelines (United Kingdom)
• Evidence-based guideline: Management of an unprovoked first seizure in adults 
  Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society (2015)
• American Academy of Neurology guideline for the treatment of neurocysticercosis (2013)
• Cavernoma-related epilepsy: Review and recommendations for management (2013)
• Recommendations for the management of febrile seizures: Ad hoc task force of LICE Guidelines Commission (2009)

Pediatric/Obstetric

• Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics (2015)
• Diagnostic test utilization in evaluation for resective epilepsy surgery in children - Report from The Task Force for Paediatric Epilepsy Surgery, Commission for Paediatrics, and the Diagnostic Commission (2014)
• ILAE Guidelines for imaging infants and children with recent-onset epilepsy (2009)
• Guidelines on Neonatal Seizures (WHO, ILAE) (2011)
• Pregnancy registries: Differences, similarities, and possible harmonization, 2010
• Infantile spasms: A U.S. consensus report, 2010
• Management issues for women with epilepsy – Focus on pregnancy, an evidence-based review:
  1. Obstetrical complications and change in seizure frequency, (2009)
  2. Teratogenesis and perinatal outcomes (2009)
  3. Vitamin K, folic acid, blood levels, and breast-feeding (2009)
• Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group (2008) | tiếng Việt Na (Vietnamese)

Antiepileptic Drugs

• Valproate in the treatment of epilepsy in Women and Girls (2015) | Português
• Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology (2013)
• Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes (2013)
• Antiepileptic drug selection for people with HIV/AIDS: Evidence-based guidelines from the ILAE and AAN, (2012)
• Antiepileptic drugs – Best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies, (2008)
• Position Statements on Generic AEDs
  Following are position statements written by Chapters of ILAE from around the world.  These are offered as a service to member of the ILAE with the intent of encouraging discussion of these issues.  None of these statements reflects the official position of the ILAE.  The ILAE does not have an official position.
• American Epilepsy Society (doc)
• French Chapter of the ILAE (pdf)
• Italian League Against Epilepsy (pdf)

Treatment, by means other than AEDs

• What are the minimum requirements for ketogenic diet services in resource-limited regions? Recommendations from the ILAE Task Force for Dietary Therapy (2015)
• Vagus nerve stimulation for the treatment of epilepsy: Report of the Guideline Development Subcommittee of the American Academy of Neurology (2013)
• Identification of new epilepsy treatments: issues in preclinical methodology (2012)
• Indian Guidelines for the Management of Epilepsy: GEMIND (2008)

Diagnosis

See also Definition of Epilepsy

• Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology (2017)
• Current standards of neuropsychological assessment in epilepsy surgery centers across Europe (2016)
• Diagnostic utility of invasive EEG for epilepsy surgery: Indications, modalities, and techniques (2016)
• New diagnostic criteria for neurocysticercosis (2016)
• Testing patients during seizures: A European consensus procedure developed by a joint taskforce of the ILAE – Commission on European Affairs and the European Epilepsy Monitoring Unit Association (2016)
• International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods (2016). (PDF)
• Quality improvement in neurology: Epilepsy Update Quality Measurement Set (Neurology, April 2015)
• Indications and expectations for neuropsychological assessment in routine epilepsy care. ILAE Neuropsychology Task Force, Diagnostic Methods Commission, March 2015. (PDF)
• International consensus classification of hippocampal sclerosis in temporal lobe epilepsy. (2013)
• Minimum requirements for the diagnosis ofpsychogenic nonepileptic seizures: A staged approach (2013)
• Standardized Computer-based Organized Reporting of EEG: SCORE (2013)
• Guidelines for Photic Stimulation (2012)
• ILAE Epilepsy imaging study guideline criteria: Commentary on diagnostic testing study guidelines and practice parameters (2011)
• ILAE Standards for epidemiologic studies and surveillance of epilepsy (2011)
• The clinico-pathological spectrum of Focal Cortical Dysplasias: A consensus classification proposed by an ad hoc task force of the ILAE Diagnostic Methods Commission (2010)
• Methodology of photic stimulation revisited: Updated European algorithm for visual stimulation in the EEG laboratory(2011)
• Genetic testing in the epilepsies: Report of the ILAE Genetics Commission (2010)
• Recommendation for a definition of acute symptomatic seizure: Report from the ILAE Commission on Epidemiology (2009)
• Definition of drug resistant epilepsy: Consensus proposal by the ad hoc task force of the ILAE Commission on Therapeutic Strategies (2009)
• Guidelines for EEG in encephalopathy related to ESES/CSWS in children (2009)
• Guidelines for Neuroimaging Evaluation of Patients with Uncontrolled Epilepsy Considered for Surgery. Commission on Neuroimaging of the ILAE (1998)
• Recommendations for Neuroimaging of Patients with Epilepsy; ILAE Commission on Neuroimaging (1997)

Other Guidelines & Reports

• Georgian Ministry of Health Guidelines and Protocols on Epilepsy (2017, Georgian versions)
• Guideline — Diagnosis and Treatment of Epilepsy
  • Protocol: Management of the first unprovoked seizure in adults
  • Protocol: Management of epilepsy in primary health care setting
  • Protocol: MRI Epilepsy Protocol
  • Protocol: MRI Epilepsy Protocol for infants and children with recent-onset epilepsy
  • Protocol: Diagnosis and management of pharmacoresistant epilepsy
• Guideline — Diagnosis, treatment, and management of status epilepticus
  • Protocol: Management of convulsive status epilepticus in children and teenagers
• How to prioritize fund raising and the funding of projects for epilepsy care and research, Milken Institute (2016)
• Revised version of quality guidelines for presurgical epilepsy evaluation and surgical epilepsy therapy issued by the Austrian, German, and Swiss working group on presurgical epilepsy diagnosis and operative epilepsy treatment (2016)
• Epilepsy Guidelines from the Province of Ontario, Canada
• Nederlandse richtlijn epilepsie
• Listening for Change: Medical and social needs of people with epilepsy and intellectual disability (2013)
• Essential services, personnel, and facilities in specialized epilepsy centers: Revised 2010 guidelines, 2010
• Report of the American Epilepsy Society and the Epilepsy Foundation joint task force on sudden unexplained death in epilepsy (2008)
• European Position on Epilepsy Research Priorities from the Commission on European Affairs (pdf)
  The CEA developed a series of broad research priorities at a workshop held January, 2008. It is intended to help focus efforts on those research questions which may have the greatest impact on understanding the mechanisms of epilepsy and on develping better treatments.  It may also be useful in discussions with others outside the field such as governmental and nongovernmental aagencies in emphasizing the need for epilepsy research and for demonstrating that the epilepsy community is united in this effort.  This paper does not represent an official position of the ILAE, but is placed here because members may find the recommendations useful.

Creating Guidelines for Publications from League Commissions and Task Forces

A key component of the ILAE's Strategic Plan is for the League to be recognized as the authoritative source for epilepsy issues that are international in scope. The League appoints Task Forces and Commissions to advise the epilepsy community about major current issues as well as to provide us with up to date definitions and classifications that become part of a common language. To assure that all publications carrying the League's name reflect this central goal, the Executive Committee has approved a set of guidelines that will govern the preparation, review and approval of reports from ILAE Task Forces and Commissions.

As described in the formal Guidelines documents, the League has established two types of reports: League Position papers and League papers. The League Position papers will be restricted to a small number of manuscripts that are designated in advance as League Position papers. These reports are generally restricted to topics that provide us common language or terminology such as classification or definitions. The League papers can be on a variety of topics (reviews, proposals, workshop reports). For this group of papers to be designated as a League publication, they must undergo formal review by Epilepsia and acceptance by the Executive Committee as meeting a level of scholarship and insight that reflects the League's goals. This designation is not automatic, and some papers may not receive the endorsement of the Executive Committee. This policy was implemented in 2014 and most above documents do not represent the official position of ILAE.

Archive

ILAE Commission Reports (2009-2015)

The following documents are no longer current and are placed here for historical perspective.

ILAE Treatment Guidelines (2006)

• Treatment Guidelines Excel spreadsheet
• Guidelines PPT Presentation