Epilepsia® Most Cited Articles

Epilepsia’s Most-Cited Articles by Publication Year

Explore the Epilepsia articles that have generated the greatest impact in the scientific community. These highly cited works continue to inform research, guide clinical decisions, and advance understanding of epilepsy worldwide.

2025 (articles published in 2024-2025)

Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy

A systematic literature review on the global epidemiology of Dravet syndrome and Lennox-Gastaut syndrome: Prevalence, incidence, diagnosis, and mortality

Over- and underreporting of seizures: How big is the problem?

Second-line immunotherapy in new onset refractory status epilepticus

Genotype-phenotype associations in 1018 individuals with SCN1A-related epilepsies

Add-on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study

Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). II. Drugs in more advanced clinical development

A comprehensive systematic literature review of the burden of illness of Lennox-Gastaut syndrome on patients, caregivers, and society

Bilateral centromedian nucleus of thalamus responsive neurostimulation for pediatric-onset drug-resistant epilepsy

Centromedian region thalamic responsive neurostimulation mitigates idiopathic generalized and multifocal epilepsy with focal to bilateral tonic-clonic seizures

2024

Over- and underreporting of seizures: How big is the problem?

A systematic literature review on the global epidemiology of Dravet syndrome and Lennox Gastaut syndrome: Prevalence, incidence, diagnosis, and mortality

Add-on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study

Second-line immunotherapy in new onset refractory status epilepticus

Genotype-phenotype associations in 1018 individuals with SCN1A related epilepsies

Current state of the epilepsy drug and device pipeline

Consensus-based recommendations for the diagnosis and treatment of anxiety and depression in children and adolescents with epilepsy: A report from the Psychiatric Pediatric Issues Task Force of the International League Against Epilepsy

Which terms should be used to describe medications used in the treatment of seizure disorders? An ILAE position paper

Metabolomic changes in adults with status epilepticus: A human case-control study

A comprehensive systematic literature review of the burden of illness of Lennox Gastaut syndrome on patients, caregivers, and society

2023

Genes4Epilepsy: An epilepsy gene resource

Treatment of seizures in the neonate: Guidelines and consensus-based recommendations Special report from the ILAE Task Force on Neonatal Seizures

Adjunctive cenobamate in highly active and ultra refractory focal epilepsy: A real-world retrospective study

Neurostimulation in generalized epilepsy: A systematic review and meta-analysis

The epidemiology of epilepsy in older adults: A narrative review by the ILAE Task Force on Epilepsy in the Elderly

Excitatory/inhibitory balance in epilepsies and neurodevelopmental disorders: Depolarizing -aminobutyric acid as a common mechanism

Are AI language models such as ChatGPT ready to improve the care of individuals with epilepsy?

Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy

Responsive neurostimulation with low-frequency stimulation

Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo controlled clinical trial