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Clinical Research

Epilepsie et troubles d'apprentissages

L’épilepsie des enfants représente une constellation de maladies neurologiques développementales de la transmission synaptique qui a grandement bénéficié des avancées des neurosciences dans la compréhension des manifestations ictales (les crises) d’une part et interictales (les troubles associés)…

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Clinical Research

Review on High Frequency Oscillations in Epilepsy

In March 2016 a workshop on High Frequency Oscillations in Epilepsy took place in Freiburg, Germany, organized primarily by Julia Jacobs. The workshop resulted in the following three publications, which summarize the current state of knowledge of this important new biomarker of epilepsy and epileptic tissue. The publications were coordinated by Maeike Zijlmans.

Basic Science

Seizure activity per se does not induce tissue damage markers in human neocortical focal epilepsy

Recurrent seizures do not induce the expression of brain damage markers in nonlesional epileptogenic cortex studied in postsurgical tissue from cryptogenic and FCD patients. This evidence argues against the hypothesis that epileptiform activity per se contributes to focal brain injury, at least in the neocortical epilepsies considered here. Ann Neurol 2017;82:331–341

Clinical Research

Underestimation of sudden deaths among patients with seizures and epilepsy

Objective: To determine the definite and potential frequency of seizures and epilepsy as a cause of death (COD) and how often this goes unrecognized. Methods: Prospective determination of seizures or epilepsy and final COD for individuals aged 18–90 years with out-of-hospital sudden cardiac…

Clinical Research

Fetal Growth and Premature Delivery in Pregnant Women on Anti-epileptic Drugs

Objective: To evaluate the effects of epilepsy and antiepileptic drugs (AED) use during pregnancy on fetal growth and preterm delivery. Methods: This study included singleton liveborns born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2016. Data…

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