In Search of Lost Time

3rd Rome workshop on rare and complex epilepsies

Istituto Patristico Augustinianum in Rome, Italy

13 - 15 December 2022

Topic: From epileptogenesis to clinical practice


Tuesday, 13 December

Session 1: Understanding Epileptogenesis in Rare Epilepsies: from basic mechanisms to clinical perspectives

  • Conceptual definition and mechanisms in the developing brain
  • Zebrafish as a model for studying early mechanisms of epileptogenesis
  • Preclinical therapeutic strategies to epileptogenesis: Gene therapy approaches
  • Clinical therapeutic strategies to epileptogenesis in Tuberous Sclerosis Complex

Session 2: Biomarkers and early diagnostic protocols in epilepsy

  • Are there innovative biomarkers, how can basic reasearch may contribute
  • Genetic biomarkers
  • Imaging biomarkers
  • EEG biomarkers
  • Integrative biomarker research (i.e.machine learning techniques)
  • Lecture : Prediction of seizures

Wednesday, 14 December

Session 3: Precision Medicine

  • Precision medicine in epilepsy: where are we now?
  • Patient-centered outcome measures in epilepsy
  • N-of-1 trials in epilepsy: where do we go?
  • Personalized medicine in epilepsy surgery: HFO and how to tailor resections
  • Personalized surgery using multimodal modelling

Session 4: Early assessment of gene variants and implication for management in rare epilepsies

  • Early detection of gene variants
  • Assessment of gene variant effect
  • Lessons learned and gaps in clinical trials for Developmental Epileptic Encephalopathies
  • Innovative clinical trial designs for Developmental Epileptic Encephalopathies

Session 5: Patient representatives

  • How registries from patients associations can help research?
  • How can patient advocates support actions for better heltcare pathways
  • What the health care providers would expect from ePAGs 

Session 6: Seizures in cluster and status epilepticus

  • Is it a cluster? Is it a status? A continuum or two distinct conditions? A clinical point of view
  • Seizures clusters in DEEs: a common emergency
  • From seizures clusters to status: a continuum or two different underlying mechanisms
  • From seizures clusters to status: could we extrapolate the therapies?
  • EpiCARE Business Session

Thursday, 15 December

Session 7: Innovative findings from early career researchers

Session 8: Therapies on Pipeline for difficult to treat epilepsies


Endorsed by the European Reference Network of Rare and Complex Epilepsies and ERN EpiCARE

Registration discounts are available for EpiCARE members.