5th Rome Debate on Developmental and Epileptic Encephalopathies

The 5th Rome Debate on Developmental and Epileptic Encephalopathies focuses on a critical and rapidly evolving challenge in pediatric neurology: understanding and treating developmental and epileptic encephalopathies (DEE) in infants with Tuberous Sclerosis Complex (TSC). Infants with TSC represent one of the most vulnerable patient groups, with a uniquely high risk of early-onset seizures, severe neurodevelopmental impairment, and long-term disability. Early identification of pathogenic mechanisms and timely intervention are essential to altering the trajectory of the disease.

This meeting aims to synthesize cutting-edge insights into the physiopathology of TSC-related DEE—including mTOR dysregulation, inflammation, metabolic interplay, and interneuronopathy—as well as emerging strategies to prevent or modify epileptogenesis. Topics such as prenatal and early postnatal mTOR inhibition, gene-based therapeutic approaches, and precision medicine will be presented by leading international experts. The programme highlights a comprehensive journey from basic mechanisms to therapeutic innovation, encouraging high-level scientific discussion and cross-disciplinary collaboration.

By bringing together neurologists, epileptologists, geneticists, neonatologists, neuroscientists, and allied health professionals, the meeting fosters a platform for debate, knowledge exchange, and envisioning future directions in early diagnosis and intervention. The ultimate goal is to advance strategies that can meaningfully improve developmental outcomes for infants affected by TSC.

This year’s edition will bring together internationally recognized experts to explore the most recent advances in the physiopathology, early diagnosis, and treatment of TSC-associated DEE. Through a series of focused presentations and live discussions, we will examine the roles of mTOR dysregulation, interneuronopathy, metabolic pathways, and gene variants in shaping disease trajectories, and we will address cutting-edge therapeutic strategies—from precision medicine to prenatal and early postnatal interventions, up to future gene-editing approaches.

The meeting offers an exceptional opportunity to exchange ideas with leaders in the field, discuss open challenges, and contribute to shaping the evolving landscape of early intervention in TSC.

Participation is free of charge, but registration is compulsory. Please register via the event website.

We warmly encourage clinicians, researchers, trainees, and all professionals involved in epilepsy, TSC, and neurodevelopmental disorders to join us for this important scientific dialogue.

We look forward to your participation.

Nicola Specchio
Paolo Curatolo