Epilepsia Open® Most Cited Articles

Epilepsia Open’s Most-Cited Articles by Publication Year

Explore the Epilepsia Open articles that have generated the greatest impact in the scientific community. These highly cited works continue to inform research, guide clinical decisions, and advance understanding of epilepsy worldwide.

2025 (articles published in 2024-2025)

Myoclonus: Differential diagnosis and current management

Refining management strategies for Lennox-Gastaut syndrome: Updated algorithms and practical approaches

Treatment simplification to optimize cenobamate effectiveness and tolerability: A real-world retrospective study in Spain

Pediatric neuromodulation for drug-resistant epilepsy: Survey of current practices, techniques, and outcomes across US epilepsy centers

The cenobamate KORK study-A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add-on lacosamide, perampanel, and brivaracetam

Spanish consensus on the management of concomitant antiseizure medications when using cenobamate in adults with drug-resistant focal seizures

Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first-line add-on therapies for seizures in Dravet syndrome: A network meta-analysis

Consensus panel recommendations for the optimization of EPIDIOLEX treatment for seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex

Stereo-electroencephalography-guided three-dimensional radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis: A retrospective study with long-term follow-up

Efficacy of anti-seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1-related epilepsy: A systematic review

2024

The cenobamate KORK study-A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add-on lacosamide, perampanel, and brivaracetam

Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first-line add-on therapies for seizures in Dravet syndrome: A network meta-analysis

Stereo-electroencephalography-guided three-dimensional radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis: A retrospective study with long-term follow-up

Pediatric neuromodulation for drug-resistant epilepsy: Survey of current practices, techniques, and outcomes across US epilepsy centers

Treatment simplification to optimize cenobamate effectiveness and tolerability: A real-world retrospective study in Spain

Efficacy of anti-seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1 related epilepsy: A systematic review

Myoclonus: Differential diagnosis and current management

Spanish consensus on the management of concomitant antiseizure medications when using cenobamate in adults with drug-resistant focal seizures

Norwegian population-based study of effectiveness of vagus nerve stimulation in patients with developmental and epileptic encephalopathies

Refining management strategies for Lennox-Gastaut syndrome: Updated algorithms and practical approaches

2023

Real-world safety and effectiveness of cenobamate in patients with focal onset seizures: Outcomes from an Expanded Access Program

EEG datasets for seizure detection and prediction- A review

Dravet syndrome: A systematic literature review of the illness burden

Real-world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study

Sudden unexpected death in epilepsy: A critical view of the literature

Status of epilepsy in the tropics: An overlooked perspective

Cenobamate in refractory epilepsy: Overview of treatment options and practical considerations

Landscape of genetic infantile epileptic spasms syndrome-A multicenter cohort of 124 children from India

Epilepsy surgery in early infancy: A retrospective, multicenter study

Antiepileptogenesis after stroke-trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate