International Symposium on the Pathophysiology of Developmental and Epileptic Encephalopathy (ISDEE2020) (The 21st Annual Meeting of the Infantile Seizure Society)

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ILAE Curriculum Learning Objectives addressed by this course

• 1.1.1 Describe the major etiologies for epilepsy (i.e. structural, genetic, infectious, metabolic, immune, and neurodegenerative) (L1)
• 1.1.2 Describe the common structural etiologies
• 1.1.3 Describe the common genetic causes of epilepsy
• 1.1.4 Describe the common infectious causes of epilepsy, including geographical impacts (e.g. bacterial, fungal, viral, parasites) (L2)
• 1.1.5 Describe the common metabolic causes of epilepsy
• 1.1.6 Describe the common immune causes of epilepsy
• 1.1.7 Describe the common neurodegenerative causes of epilepsy
• 1.2.1 Decide on which patients to do genetic testing (L2)
• 1.2.2 Decide what type of genetic testing to conduct (L3)
• 1.2.3 Interpret and apply the results of genetic testing accurately in the clinical context (L3)
• 1.3.1 Learn and recognize the seizure semiology and distinguish it from other non-epileptic manifestations
• 1.3.2 Extract semiology information from patient history
• 1.3.3 Extract semiology information from video recordings
• 1.3.4 Interpret semiological signs and symptoms allowing hypotheses on the localization of focal seizures
• 1.3.5 Interpret semiological signs and symptoms suggesting focal vs. generalized onset
• 1.3.6 Classify seizures according to the ILAE classification
• 1.4.10 Recognize and describe ictal patterns (L2)
• 1.4.11 Recognize and describe ictal and interictal patterns with intracranial recordings (L3)
• 1.4.9 Recognize and describe interictal abnormalities (L2)
• 1.5.1 Recognize the spectrum of MRI sequences optimized for epilepsy (L2)
• 1.5.2 Decide on whom to do structural neuroimaging (L1)
• 1.5.3 Decide when to conduct neuroimaging and repeat as needed (L2)
• 1.5.4 Decide when to conduct specialized neuroimaging and which type
• 1.5.5 Interpret and apply the results of specialized neuroimaging accurately in the clinical context (L3)
• 1.6.1 Decide which patients should receive lab tests and which types of tests should be ordered (L1)
• 1.7.1 Accurately distinguish acute symptomatic seizures from epilepsy (L1)
• 1.7.2 Correctly distinguish between focal and generalized epilepsies and recognize epileptic encephalopathies (L1)
• 1.7.3 Correctly diagnose and classify focal epilepsies (L2)
• 1.7.4 Correctly diagnose and classify generalized epilepsies (L1)
• 1.7.5 Correctly diagnose and classify combined focal and generalized epilepsies including epileptic encephalopathy (L2)
• 2.2.1 Provide guidance on social issues including school integration, work, legal, and related aspects (L1)
• 2.3.1 Communicate to patients and families as appropriate (L1)
• 2.3.2 Educate patients and family about the disease specifics (L2)
• 2.3.3 Educate caregivers about the clinical condition and its management (L2)
• 2.3.4 Educate workplace or school stakeholders concerning the patient's needs (L3)
• 2.3.5 Provide information to patients regarding potential adverse effects of antiepileptic drugs (L1)
• 2.3.6 Counsel patients and family regarding the risks and benefits of epilepsy surgery (L3)
• 2.4.2 Advise patients with uncontrolled seizures (L2)
• 2.5.1 Recognize when to refer patients for higher level of care (L1)
• 2.9.1 Provide counseling specific to children with epilepsy and their parents, according to the epilepsy-types (L2)
• 3.1.1 Identify the spectrum of action for antiepileptic drugs (L1)
• 3.1.2 Demonstrate knowledge of pharmacokinetics and pharmacodynamics (L1)
• 3.1.3 Demonstrate knowledge regarding the adverse effects of antiepileptic drugs (L1)
• 3.1.4 Demonstrate knowledge of appropriate monitoring of AES serum levels (L2)
• 3.1.5 Demonstrate knowledge about drug interactions (e.g. enzyme induction, etc.) for AED/AED and AED/concomitant medication
• 3.1.6 Demonstrate knowledge about treatment of psychiatric and cognitive comorbidities in children and adults (L3)
• 3.2.1 Recommend appropriate therapy according to seizure type (L1)
• 3.2.2 Recommend appropriate therapy according to epilepsy syndrome (L2)
• 3.2.3 Recommend individualized titrations of optimal dosing for patients including starting and discontinuing medication (L1)
• 3.2.4 Communicate information regarding the antiepileptic drug regimen (L1)
• 3.2.5 Recommend second- and third-line treatments as necessary (L2)
• 3.3.2 Define treatment strategies considering issues specific to neonates and very young children (L3)
• 3.3.5 Define treatment strategies considering genetic markers (L3)
• 3.3.7 Define treatment strategies for immune mediated causes of epilepsy and seizures (L2)
• 3.5.1 Identify patients who are drug resistant according to the current ILAE definition (L1)
• 3.6.1 Demonstrate knowledge of indications, limitations and risks for ketogenic diets (L3)
• 3.7.1 Demonstrate knowledge of indications, limitations, and risks for vagal nerve stimulation and other neuromodulation techniques (L3)
• 4.1.1 Demonstrate working knowledge of indications for pre-surgical evaluation (L1)
• 4.2.1 Describe the importance of early surgical intervention regarding neuro-developmental, cognitive, behavioral and social integration aspects (L2)
• 4.3.1 Recommend and interpret video-EEG monitoring as appropriate) (L3)
• 4.3.2 Recommend functional neuroimaging as appropriate (L3)
• 4.3.3 Recommend and interpret results of neuropsychological testing (L3)
• 4.3.4 Demonstrate working knowledge on planning implantation of intracranial electrodes (L3)
• 4.4.1 Demonstrate working knowledge of etiologies amenable to surgical treatment and their prognoses in all age groups (L2)
• 4.5.1 Demonstrate ability to integrate information from multi-modal work-up and estimate risks and benefits of surgical therapy (L3)
• 4.6.1 Demonstrate knowledge about the risks and benefits associated with drug management (L3)
• 4.6.2 Demonstrate working knowledge of post-surgical neurological and psychiatric complications (L3)
• 4.6.3 Identify situations which require consideration of repeated surgery (L3)
• 4.6.4 Identify situations which require rehabilitation following surgery (L3)
• 4.7.1 Demonstrate the value and need for multidisciplinary teamwork (L3)
• 5.1.1 Articulate the conditions or elements that constitute an emergency (L1)
• 5.1.2 Appropriately manage or advise regarding prolonged or sequential seizures (L1)
• 5.2.1 Appropriately diagnose all types of convulsive status epilepticus (L1)
• 5.2.2 Appropriately diagnose all types of nonconvulsive status epilepticus including EEG interpretations
• 5.3.1 Appropriately manage all types of convulsive status epilepticus including EEG monitoring of treatment effect (L2)
• 5.3.2 Appropriately manage all types of nonconvulsive status epilepticus including EEG monitoring of treatment effect (L2)
• 6.1.1 Recognize psychiatric comorbidities, such as depression, anxiety, attention deficit and hyperactivity disorder, psychosis and autism spectrum disorders (L2)
• 6.1.2 Appropriately manage or advise regarding psychiatric comorbidities (L2)
• 6.1.3 Adjust anti-seizure treatment as required by psychiatric comorbidities (L2)
• 6.1.4 Demonstrate the ability to recognize and manage the special needs of persons with epilepsy (L3)
• 6.1.5 Manage cognitive changes in epilepsy and the cognitive effects of AEDs (L2)
• 6.2.1 Diagnose somatic comorbidities, such as those related to epilepsy treatment, causes of epilepsy, or common associated conditions (L2)
• 6.2.2 Appropriately manage and advise regarding somatic comorbidities (L2)
• 6.2.3 Adjust anti-seizure treatment as required by common somatic comorbidities (L2)
• 7.1.1 Demonstrate working knowledge of ictogenesis (L3)
• 7.2.1 Demonstrate working knowledge of epileptogenesis (L3)
• 7.3.1 Demonstrate awareness of animal models for focal and generalized epilepsies (L3)
• 7.4.1 Demonstrate knowledge of bidirectional relationship between epilepsy and psychiatric comorbidities (L3)