Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis
Zahra Shiri, Maxime Levesque, Guillaume Etter, Frederic Manseau, Sylvain Williams, and Massimo Avoli Contributed by Sloka S. Iyengar, PhD.
Contributed by Sloka Iyengar
Journal of Neuroscience 15 March 2017 37 (11) 2999-3008; DOI: https://doi.org/10.1523/JNEUROSCI.2244-16.2017
This study was done to investigate whether LFS with optogenetic stimulation of calcium/calmodulin-dependent protein kinase II-positive (CaMKII-positive) principal cells, and parvalbumin or somatostatin-positive interneurons was able to reduce epileptiform activity caused by 4-AP in the entorhinal cortex (EC). Targeting all three cell types led to a reduction in ictal activity, but the effect was greater when CaMKII-positive principal cells were targeted. These results are promising because they suggest that seizures can be targeted temporally (through LFS) and selectively (through optogenetics); the results of this study may have potential favorable implications for refractory epilepsy. More …
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