Commission on Neurobiology
Preclinical epilepsy common data elements (EPICDE)
The ILAE/AES Joint Translational Task Force in collaboration with LONI Resource investigators at the University of Southern California have created electronic case report forms (eCRFs) of the preclinical epilepsy common data elements (CDEs) proposed by the TASK3 working groups on core, physiology and EEG CDEs. Materials for implementing a REDCap project aligned with the ILAE/AES Joint Translational Task Force CDEs can be downloaded from this zip file.
The project has been sponsored by the International League Against Epilepsy (ILAE), American Epilepsy Society (AES), and CURE Epilepsy. The eCRFs have been created by the LONI Resource Investigators. Please see the acknowledgements for detailed information on contributors.
For more information on the preclinical CDEs, please contact Aristea Galanopoulou.
Additional information on the TASK3 CDEs is included in the companion papers published in the special issue on "Preclinical common data elements of the ILAE/AES Joint Translational Task Force" of Epilepsia Open.
Lay Summary of Epilepsia Special Issue: Harmonization in Preclinical Epilepsy Research
Harmonization in preclinical epilepsy research: a joint AES/ILAE translational initiative.
Aristea S. Galanopoulou; Jacqueline A. French; Terence O’Brien; Michele Simonato
The optimization and harmonization of research practices in preclinical epilepsy research has been considered as an important translational initiative as it would allow data comparisons across laboratories, encourage multicenter collaborations and systematic reviews of preclinical data, as well as allow cross-validation of findings before entering clinical testing. The AES/ILAE Translational Task Force, a joint task force formed of members elected from the American Epilepsy Society (AES) and the International League Against Epilepsy (ILAE) undertook several initiatives towards this goal. A large number of volunteer investigators were assigned into different topic-oriented working groups. This introduction to the special issue on the proceedings of this Task Force describes the first reports that were produced by some of these working groups towards the creation of improved standards for performing and interpreting rodent electroencephalography (EEG) and electrophysiological studies, systematic reviews of preclinical data, and preclinical common data elements.
ILAE Genetics Commission blog
Interested in some general reading about the genetics and molecular neurobiology of epilepsies? Try the ILAE Genetics Commission blog: http://channelopathist.net/)
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