ILAE-Eastern Mediterranean


Nature Reviews Neurology
Clinical Research

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

In this Review, we focus on our understanding of the IL-1 receptor–Toll-like receptor 4 axis, the arachidonic acid–prostaglandin cascade, oxidative stress and transforming growth factor-β signalling associated with blood–brain barrier dysfunction, all of which are pathways that are activated in pharmacoresistant epilepsy in humans and that can be modulated in animal models to produce therapeutic effects on seizures, neuronal cell loss and neurological comorbidities.

30 July, 2019