ILAE-Europe
News
Clinical Research
Association of Levels of Specialized Care With Risk of Premature Mortality in Patients With Epilepsy
Exposure to specialist care is associated with incremental reductions in the hazard of premature mortality. Those referred to a comprehensive epilepsy program received the greatest benefit.
6 August, 2019
Clinical Research
Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy
The subicular pyramidal neurons may be a key “switch” control of drug resistant epilepsy and represent a new potential target for precise treatments.
5 August, 2019
About ILAE
In memoriam Jerzy Majkowski
We are deeply saddened to announce that Jerzy Majkowski Emeritus Professor of Neurology and father of the Polish League Against Epilepsy, passed away on July 18 2019 in Warsaw at age 91. He contributed much in area of neurophysiology and epileptology. He trained and inspired a large number of…
31 July, 2019
Clinical Research
Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy
In this Review, we focus on our understanding of the IL-1 receptor–Toll-like receptor 4 axis, the arachidonic acid–prostaglandin cascade, oxidative stress and transforming growth factor-β signalling associated with blood–brain barrier dysfunction, all of which are pathways that are activated in pharmacoresistant epilepsy in humans and that can be modulated in animal models to produce therapeutic effects on seizures, neuronal cell loss and neurological comorbidities.
30 July, 2019
Clinical Research
Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals
Our study, the largest epilepsy WES study to date, confirms a convergence in the genetics of severe and less-severe epilepsies associated with ultra-rare coding variation, and it highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology.
30 July, 2019
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